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CBD Oil Studies: Scientific Validation & Potential

Scientific journals (scholarly, peer-reviewed) on the effects of CBD on the human body, the ECS system, and even our pets. For plain(er) reading, scroll to the Executive Summaries where available.

“Cannabinoids, the active components of Cannabis sativa, and endogenous cannabinoids mediate their effects through activation of specific cannabinoid receptors known as cannabinoid receptor 1 and 2 (CB1 and CB2).

•The cannabinoid system has been shown both in vivo and in vitro to be involved in regulating the immune system through its immunomodulatory properties.

•Cannabinoids suppress inflammatory response and subsequently attenuate disease symptoms. This property of cannabinoids is mediated through multiple pathways such as induction of apoptosis in activated immune cells, suppression of cytokines and chemokines at inflammatory sites and upregulation of FoxP3+ regulatory T cells.

•Cannabinoids have been tested in several experimental models of autoimmune disorders such as multiple sclerosis, rheumatoid arthritis, colitis and hepatitis and have been shown to protect the host from the pathogenesis through induction of multiple anti-inflammatory pathways.

•Cannabinoids may also be beneficial in certain types of cancers that are triggered by chronic inflammation. In such instances, cannabinoids can either directly inhibit tumor growth or suppress inflammation and tumor angiogenesis.”

Nagarkatti, P., Pandey, R., Rieder, S. A., Hegde, V. L., & Nagarkatti, M. (2009). Cannabinoids as novel anti-inflammatory drugs. Future medicinal chemistry, 1(7), 1333-49.      

“Veterinarians in the current sample overwhelmingly support further research into both the therapeutic use and toxicity of CBD as well as the toxicity of marijuana. The majority do not feel that CBD or marijuana should remain defined as Schedule I drugs by the DEA, nor feel that these substances should remain illegal for use in animals or humans. Taken together, these responses suggest that the veterinary community is receptive to exploring the potential of cannabis products and hungers for scientific data and clinical trials.”

Kogan, L., Schoenfeld-Tacher, R., Hellyer, P., & Rishniw, M. (2019). US Veterinarians’ Knowledge, Experience, and Perception Regarding the Use of Cannabidiol for Canine Medical Conditions. Frontiers in Veterinary Science, 5, 338. doi:10.3389/fvets.2018.00338

“Human and animal studies suggest that CBD may offer therapeutic benefits for disorders related to inappropriate responses to traumatic memories. The effects of CBD on the different stages of aversive memory processing make this compound a candidate pharmacological adjunct to psychological therapies for PTSD. CBD also shows an action profile with fewer side effects than the pharmacological therapy currently used to treat this type of disorder. In addition, even at high doses, CBD does not show the anxiogenic profile of compounds that directly activate eCB transmission.” A call for further research and study is noted.

Bitencourt, R. M., & Takahashi, R. N. (2018). Cannabidiol as a Therapeutic Alternative for Post-traumatic Stress Disorder: From Bench Research to Confirmation in Human Trials. Frontiers in neuroscience, 12, 502. doi:10.3389/fnins.2018.00502